gltT [2017-08-07 10:37:03]

major high-affinity Na -coupled glutamate/ aspartate symport protein

Locus: BSU10220

Isoelectric point: 9.03

Molecular weight: 45.76 kDa

Protein length: 429 aa

Gene length: 1287 bp

Function: glutamate and aspartate uptake

Product: major Na -coupled glutamate/ aspartate symport protein

Essential: no

Synonyms: yhfG

Genomic Context

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Categories containing this gene/protein

• Cellular processes → Transporters → Transporters/ other → Amino acid transporters → Solute:sodium symporter family
• Cellular processes → Transporters → Transporters/ other → Amino acid transporters → Dicarboxylate/amino acid:cation symporter
• Metabolism → Amino acid/ nitrogen metabolism → Biosynthesis/ acquisition of amino acids → Biosynthesis/ acquisition of glutamate/ glutamine/ ammonium assimilation
• Metabolism → Amino acid/ nitrogen metabolism → Utilization of amino acids → Utilization of glutamine/ glutamate
• Groups of genes → Membrane proteins

Gene

Coordinates: 1,096,560 → 1,097,849

Phenotypes of a mutant

• impaired uptake of glutamate and aspartate PubMed

The protein

Protein family

• View classification (according to Swiss-Prot)

Paralogous protein(s)

• GltP, DctP

Structure

• 4IZM (the protein from Pyrococcus horikoshii, 35% identity, 73% similarity) PubMed
• 4KY0 (the glutamate transporter of Thermococcus kodakarensis, 35% identity, 72% similarity) PubMed

Localization

• cell membrane PubMed

Expression and Regulation

Operons

• Genes: gltT
  Description: PubMed

Biological materials

Mutant

• GP2247 (gltT::ermC), available in Jörg Stülke's lab
• GP2248 (gltT::aphA3), available in Jörg Stülke's lab
• available in Erhard Bremer's lab PubMed

References

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